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目的联合应用两种对于早产预测的敏感性、特异性、阳性及阴性预测值均较高的方法,进一步提高早产的预测率,提高对于早产发生时间的预测准确度,对预测阳性者及早进行有效干预,改善围产儿结局。方法符合入组条件的孕妇,取膀胱结石位,常规消毒外阴、窥器暴露宫颈后取宫颈管内分泌物,测定宫颈胰岛素样生长因子结合蛋白-1(IGFBP-1)后再使用GE-E8型彩超经阴道测量宫颈结构,并计算出宫颈指数。结果 IGFBP-1阳性对于早产预测的阳性率为65.0%;阴性预测率为89.1%。宫颈指数(<0.5)对于早产预测的阳性率为60.0%;阴性预测率为91.7%。二者结合对于早产预测的阳性率为90.0%;阴性预测率为96.7%。结论测定宫颈IGFBP-1,并行超声测量宫颈管产度二者联合对于预测早产的发生明显优于单一方法。
OBJECTIVE To jointly improve the predictive value of preterm delivery and improve the predictive accuracy of preterm birth by combining two of the above methods with high sensitivity, specificity, positive and negative predictive values for predicting preterm birth, Intervention to improve perinatal outcome. Methods Pregnant women who met the inclusion criteria were treated with GE-E8 by measuring the level of bladder stones, routinely disinfecting the vulva, exposing the cervical canal to endocrine secretions after examining the cervix and measuring the insulin binding factor-1 (IGFBP-1) Color Doppler ultrasound cervical structure, and calculate the cervical index. Results The positive rate of IGFBP-1 positive predictive value for preterm birth was 65.0% and the negative predictive value was 89.1%. The cervical index (<0.5) predicted a positive rate of 60.0% for preterm birth and a negative predictive rate of 91.7%. The combination of the two for the prediction of preterm birth was 90.0%; negative predictive rate was 96.7%. Conclusion The combination of IGFBP-1 measured by cervical canal and uterine cervix tube measured by ultrasound is superior to the single method in predicting the incidence of preterm labor.