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急性早幼粒细胞白血病(以下简称APL)在确定为独立疾病以前,人们已知在急性粒细胞白血病中有一型有明显的出血倾向,其病程激进,迅速导致死亡.1957年Hillestad建议称之为急性早幼粒细胞白血病,当时的定义为:(1)类早幼粒白血病细胞占多数;(2)血小板减少;(3)血沉不快;(4)由于明显的出血倾向,病程经过激进而死亡.现在虽然仍延用Hillestad的定义,但对上述四项做了以下的解释:(1)对化疗反应不好;(2)血液象异形早幼粒细胞占优势;(3)由于血管内凝血而致血小板、纤维蛋白原、第V及第Ⅷ因子减少.即本病是以类早幼粒细胞的增殖和明显的凝血异常为特征的疾病.
Acute promyelocytic leukemia (hereinafter referred to as APL) was identified as an independent disease before, it is known that in acute myeloid leukemia, there is a type of obvious bleeding tendency, the course of its illness, led to rapid death in 1957 Hillestad recommended that Acute promyelocytic leukemia was defined at the time as: (1) a majority of promyelocytic leukemia cells; (2) thrombocytopenia; (3) unpleasant edema; (4) an aggressive course of death due to a significant bleeding tendency . Although the definition of Hillestad is still used now, the following four explanations have been given: (1) poor response to chemotherapy; (2) blood like promyelocytic predominance; (3) blood clotting due to intravascular coagulation The resulting platelets, fibrinogen, V and factor â ... ¤ reduced, that is, the disease is characterized by promyelocytic proliferation and obvious coagulation disorders.