论文部分内容阅读
[目的]了解肿瘤坏死因子(TNFβ)-G252A基因多态性与海南黎族急性脑梗塞之间的关系。[方法]应用多聚酶链反应技术(PCR)检测和比较84例动脉硬化性脑梗塞和79例正常对照人群的TNFβ-G252A基因的多态性,统计各组基因型频率及各组等位基因频率。[结果]TNFβ-G252A基因多态性和频率在急性脑梗塞组与正常对照组间差异有统计学意义(χ2=9.216,P﹤0.05;χ2=93.507,P﹤0.05)。[结论]TNFβ-G252A基因多态性与海南黎族急性脑梗塞发病相关。
[Objective] To investigate the relationship between tumor necrosis factor (TNFβ) -G252A gene polymorphism and acute cerebral infarction in Hainan Li ethnicity. [Methods] The polymorphisms of TNFβ-G252A gene in 84 patients with arteriosclerotic cerebral infarction and 79 normal controls were detected and compared by polymerase chain reaction (PCR). The genotype frequency and allele frequency . [Results] The polymorphism and frequency of TNFβ-G252A gene were significantly different between acute cerebral infarction group and normal control group (χ2 = 9.216, P <0.05; χ2 = 93.507, P <0.05). [Conclusion] The TNFβ-G252A gene polymorphism is associated with the incidence of acute cerebral infarction in Hainan Li ethnicity.