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目的:研究MUC 4在口腔疣状癌的表达情况,探讨其在口腔疣状癌发生发展中的作用。方法:采用免疫组织化学方法,对18例口腔疣状癌、26口腔鳞癌和14例正常口腔黏膜MUC 4蛋白进行检测,并与临床病理参数比较。结果:口腔疣状癌和鳞癌组织中MUC 4蛋白表达显著高于正常黏膜(P<0.05),不同临床类型口腔疣状癌的蛋白表达无显著差异(P>0.05);MUC 4蛋白的表达与性别、年龄、发病部位、临床分期无显著相关(P>0.05)。结论:口腔疣状癌和鳞癌中MUC 4蛋白呈上调表达,蛋白的表达可能与肿瘤的恶性程度相关。
Objective: To investigate the expression of MUC 4 in oral verrucous carcinoma and its role in the development of oral verrucous carcinoma. Methods: 18 cases of oral verrucous carcinoma, 26 oral squamous cell carcinomas and 14 cases of normal oral mucosa MUC 4 protein were detected by immunohistochemical method and compared with clinicopathological parameters. Results: The expression of MUC 4 protein in oral verrucous carcinoma and squamous cell carcinoma tissues was significantly higher than that in normal mucosa (P <0.05). There was no significant difference in the expression of MUC 4 protein between different clinical types of oral verrucous carcinoma (P> 0.05) There was no significant correlation with gender, age, disease location and clinical stage (P> 0.05). Conclusion: MUC 4 protein in oral verrucous carcinoma and squamous cell carcinoma is up-regulated, and protein expression may be related to the malignancy of the tumor.