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目的分析54例四川籍哮喘儿童IL-4基因C-589T多态性与白细胞数量之间的关系,为哮喘的辅助性诊断提供依据。方法选取有喘息症状1~2次或夜间咳嗽症状的儿童54例,检测IL-4基因C-589T基因多态性及白细胞数量。结果CC型、CT型、TT型的分布频率依次为67.27%、27.27%、5.45%。C-589T的CC型、CT型与TT型患儿白细胞数量比较,差异有统计学意义(P<0.05),TT型患儿白细胞水平明显高于CC型及CT型。结论 C-589T(IL-4)基因多态性与白细胞数量相关,可以为儿童哮喘诊断提供一定的依据。
Objective To analyze the relationship between C-589T polymorphism of interleukin-4 (IL-4) gene and the number of white blood cells in 54 asthmatic children with asthma in Sichuan Province, and to provide a basis for the diagnosis of asthma. Methods Fifty-four children with wheezing symptoms or nocturnal cough were selected to detect the polymorphism of C-589T gene and the number of leukocytes. Results The distribution frequencies of CC type, CT type and TT type were 67.27%, 27.27% and 5.45%, respectively. The number of leukocytes in C-589T CC, CT and TT children was significantly higher than that in CC and CT (P <0.05). Conclusion The polymorphism of C-589T (IL-4) gene is correlated with leukocyte count, which may provide a basis for the diagnosis of childhood asthma.