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1975年 Samullon 等发现前列腺素(PG)内过氧化物在血小板内能产生一种强烈的,使血管收缩和血小板聚积物质,后定名为血栓素(TXA_2),次年 Moncada 和 Vane~2又发现一个与 TXA_2作用完全相反的物质
In 1975, Samullon et al. Found that peroxynitrite in prostaglandin (PG) produced an intense intravascular platelet aggregation product called thromboxane (TXA_2) in platelets. In the following year, Moncada and Vane ~ 2 were found again A substance that acts exactly the opposite of TXA_2