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为阐明流行性出血热(简称出血热)的出血机理,我们将31例出血热患者各病期血小板和红细胞涂片,用羊抗人IgG和C3荧光素作荧光染色后,再用出血热单克隆荧光抗体作特异性染色。血小板、红细胞表面的免疫复合物在发热期即出现,检出率分别为33.3％和25.8％,至休克少尿期仍存在,到多尿和恢复期则基本消失。发热期患者的血小板计数及其聚集率均显著下降。各病期血标本纤维蛋白原半定量测定的结果均属正常。但纤维蛋白(原)裂解产物(FDP)在发热期已有增高,休克少尿期增高显著,多尿期仍高于正常。直至恢复期渐趋正常。本文资料提示免疫复合物在组织细胞表面沉积是引起出血的重要原因。
In order to elucidate the hemorrhagic mechanism of epidemic hemorrhagic fever (hemorrhagic fever), 31 cases of hemorrhagic fever patients at various stages of platelet and erythrocyte smear, with sheep anti-human IgG and C3 fluorescein for fluorescent staining, and then a single Clone fluorescent antibodies for specific staining. The immune complexes on platelets and erythrocytes appeared during the fever period, with the detection rates of 33.3% and 25.8% respectively. The oliguric phase was still present in shock and disappeared in the period of polyuria and convalescence. Patients in the febrile period platelet count and aggregation rate were significantly decreased. All stages of blood fibrinogen semi-quantitative determination of the results are normal. However, fibrinogen (FDP) pyrolysis products (FDP) have increased in the fever, shock increased significantly oliguria, polyuria is still higher than normal. Until the recovery period getting normal. The data suggest that the deposition of immune complexes on the surface of tissue cells is an important cause of bleeding.