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为检测我国健康汉族人群载脂蛋白AⅣ的多态性，用等电聚焦电泳和免疫印迹技术检测了180名健康汉族人载脂蛋白AⅣ的基因频率和表型分布。结果发现，载脂蛋白AⅣ的等位基因AⅣ*2和AⅣ*2的出现频率分别为99．44％和0．28％；两种常见表型载脂蛋白AⅣ－1／1和AⅣ－2／1的分布分别为98．89％和0．56％。与欧美等西方国家人群相比有显著性差异（P＜0．05），与日本和马来西亚人相比无显著性差异（P＞0.05）。提示，不同种族的人群载脂蛋白AⅣ的基因频率和表型分布不相同，推测我国汉族人群以载脂蛋白AⅣ*1等位基因和载脂蛋白AⅣ－1／1表型分布为主。
To detect the polymorphism of apolipoprotein AⅣ in healthy Han population of China, the gene frequency and phenotype distribution of apolipoprotein AⅣ in 180 Han healthy people were detected by isoelectric focusing electrophoresis and Western blotting. The results showed that the frequencies of AIV * 2 and AIV * 2 of the apolipoprotein AⅣ were 99.44% and 0.28% respectively. The two common phenotypic apolipoproteins AⅣ-1/1 and AⅣ-2 / 1 distribution were 98.89% and 0.56% respectively. There was a significant difference (P <0.05) between western and eastern populations in Europe and the United States, but no significant difference between Japanese and Malaysians (P> 0.05). These results suggest that the gene frequency and phenotype distribution of apolipoprotein AⅣ in different ethnic groups are different. It is presumed that the phenotypic distribution of apolipoprotein AⅣ * 1 allele and apolipoprotein AⅣ-1/1 is predominant in Chinese Han population.