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目的测定慢性肾功能衰竭肾性贫血患者的血清铁参数,探讨肾性贫血患者的铁代谢状况以及在诊疗过程中的临床意义。方法测定正常对照组与慢性肾功能衰竭(CRF)组不同阶段患者的血肌酐(Scr)、血红蛋白(Hb)、红细胞压积(Hct)、血清铁蛋白(SF)、血清铁(SI)、总铁结合力(TIBC)、转铁蛋白饱和度(TS)及白细胞介素1(IL-1)指标,并进行t检验。结果慢性肾功能衰竭患者血清中Hb、Hct、SI、TIBC、TS显著低于健康对照组(P<0.01),SF、IL-1显著高于健康对照组(P<0.01)。结论肾性贫血患者存在铁代谢紊乱,转铁发生障碍,有铁超负荷的倾向。
Objective To determine serum iron parameters in patients with chronic renal failure and renal anemia and to explore the status of iron metabolism in patients with renal anemia and its clinical significance in the diagnosis and treatment. Methods The levels of serum creatinine (Scr), hemoglobin (Hb), hematocrit (Hct), serum ferritin (SF), serum iron (SI) and plasma total cholesterol in patients with chronic renal failure (CRF) (TIBC), transferrin saturation (TS) and interleukin-1 (IL-1) were measured and t test was performed. Results Serum levels of Hb, Hct, SI, TIBC and TS in patients with chronic renal failure were significantly lower than those in healthy controls (P <0.01). SF and IL-1 in serum were significantly higher than those in healthy controls (P <0.01). Conclusions Patients with renal anemia have disorder of iron metabolism, disturbance of transfer of iron, and tendency of iron overloading.