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Objective: To explore the correlation of nonalcoholic fatty liver (NAFL) with insulin resistrandomly assigned into the treated group and the control group. They were treated with GKY and Silymarin for 3 months respectively. Oral glucose tolerance test (OGTT) and insulin release test (IRT) were conducted and insulin sensitivity indexes were determined before and after treatment. And 32 healthy nonalcoholic persons were enrolled and used as the healthy control group. Results: Before treatment, the levels of blood glucose and insulin at different time points in OGTT test, and the insulin resistance index (IRI) were significantly higher (P＜0.05 or P＜0.01) while insulin sensitivity index (ISI) and insulin active index (IAI) were lower ( P＜0.05 or P＜0. 01) in the NAFL patients than those in the healthy persons. After treatment, the abovementioned raised criteria were significantly Iowered ( P＜0. 05, P＜0.01) and the lowered criteria were significantly increased ( P＜0. 01) in the treated group, while in the control group all the criteria were insignificantly changed ( P ＞0.05 ). Conclusion: Evident insulin resistance exists in NAFL patients. GKY could increase the insulin sensitivity, thus improving the state of insulin resistance in NAFL patients.