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目的：探讨护理干预在减少或减轻前列地尔注射不良反应中的作用。方法回顾性分析2013年1月~2015年1月门诊输注注射用前列地尔患者100例，随机分为观察组及对照组，各50例，观察组在输液前给予心理干预，对比分析两组患者发生不良反应的例数及程度。结果经过对比分析，观察组发生不良反应明显低于对照组，差异有统计学意义（<0.05）。结论通过对输注注射用前列地尔患者给予恰当的护理干预，能明显减少不良反应的发生。“,”Objective To explore the effects of nursing interventions to reduce or mitigate the adverse reactions of prostaglandin E1 injection.Methods A retrospective analysis was performed on 100 outpatients who were injected with prostaglandin E1from January 2013 to January 2015.A comparative analysis was implemented to find the difference in the number of the patients with adverse reactions and the degree of adverse reaction.Results The adverse reactions in observation group was obviously lower than that in control group,the difference was statistically significant ( <0.05).Conclusion The nursing intervention in the patients injected with prostaglandin E1 can obviously decrease the occurrence of adverse reactions so as to protect the injection safety of the patients.