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目的 为研究尿视黄醇结合蛋白 (RBP)在诊断糖尿病早期肾病中的价值及与尿α1 球蛋白 (α1 MG)、尿白蛋白 (A1b)之间的关系。方法 用酶联免疫法测定了 90例 2型糖尿病患者及 38例健康对照者的尿RBP ,用放射免疫法 (放免法 )测定了白蛋白排泄量 (UAE)及尿α1 MG。结果 糖尿病组尿RBP明显高于正常对照组 (P <0 0 1) ,且随着UAE的增高 ,尿RBP明显增高 ;尿RBP与UAE及尿α1 MG均呈显著正相关 (P均 <0 0 1) ;在正常白蛋白尿组中 ,当尿白蛋白排泄尚正常时 ,发现已有 10例尿RBP增高 ,7例尿α1 MG增高 ,提示部分糖尿病患者在肾小球损害前 ,可能已存在肾小管的损害。结论 尿RBP排泄量增高可作为早期糖尿病肾病肾小管损害的检测指标之一
Objective To investigate the value of urinary retinol binding protein (RBP) in the diagnosis of early diabetic nephropathy and its relationship with urinary α1 globulin (α1 MG) and urinary albumin (A1b). Methods Urinary RBP was measured in 90 patients with type 2 diabetes mellitus and 38 healthy controls by enzyme-linked immunosorbent assay. The albumin excretion (UAE) and urinary α1 MG were measured by radioimmunoassay (RIA). Results The urinary RBP in diabetic group was significantly higher than that in normal control group (P <0.01), and the urinary RBP was significantly increased with the increase of UAE. Urinary RBP was positively correlated with UAE and urinary α1 MG (P <0.01) 1). In normal albuminuria group, when urinary albumin excretion was still normal, it was found that 10 cases of urinary RBP increased, and 7 cases of urinary α1 MG increased, suggesting that some patients with diabetes before glomerular damage may already exist Tubular damage. Conclusions Increased urinary RBP excretion may be one of the indicators of renal tubular damage in early diabetic nephropathy