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对药物的评价不仅决定于治疗剂量的大小,还取决于药物治疗剂量与中毒剂量差距的大小(即治疗指数及安全限).我们在寻找抗肿瘤新药的研究中,发现N-甲酸溶肉瘤素(以下简称N-甲)有明显的抗肿瘤作用.从化学结构看来,N-甲与溶肉瘤素非常相似,但临床观察表明,N-甲对溶肉瘤素不敏感的淋巴肉瘤、何杰金氏病却有明显疗效.因此,我们对N-甲及溶肉瘤素在三种动物肿瘤作用的效价进行了比较.本文即研究初步结果的简报.材料及方法药物系由我所药物化学系合成室供给.N-甲批号是6103,熔点为148-151℃,实验前将药物混悬于2％淀粉糊中.溶肉瘤素批号是S615,熔点为178-181℃,实验前将药物用70-80℃蒸馏水溶解,现用现配.
The evaluation of the drug depends not only on the size of the therapeutic dose, but also on the size of the difference between the dose of the drug and the dose of poisoning (ie, therapeutic index and safety limit) .In the search of new antitumor drugs, we found that N-formicolysin (Hereinafter referred to as N-A) has obvious antitumor effect.From the chemical structure, N-A and thalassemia is very similar, but the clinical observations show that N-methyl-thalassensin-sensitive lymphosarcoma, He Jie Therefore, we compared the potency of N-A and lysostaphin in the tumor action of three animals.This article is a briefing to study the preliminary results.Materials and Methods The drug was produced by our Institute of Pharmaceutical Chemistry Department of synthesis room supply.N-A batch number is 6103, the melting point of 148-151 ° C, before the experiment the drug was suspended in 2% starch paste.Satkosinoid Lot is S615, the melting point of 178-181 ° C, before the experiment drug Dissolved with distilled water 70-80 ℃, now with the current.