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目的：初步探讨噻氯匹定对肾病综合征高凝状态的作用。方法：６７例肾病综合征患者随机分成２组，治疗组３３例采用噻氯匹定加强的松治疗，对照组３４例单用强的松治疗，观察２组尿蛋白、血白蛋白、血肌酐、胆固醇、低密度脂蛋白、极低密度脂蛋白、尿纤维蛋白降解产物、血小板最大聚集率等指标变化。结果：治疗组血清白蛋白、胆固醇、低密度脂蛋白、极低密度脂蛋白、尿纤维蛋白降解产物、血小板最大聚集率与对照组比较差异有显著性（Ｐ＜０．０５）。结论：噻氯匹定加强的松治疗肾病综合征高凝状态疗效明显优于单用强的松
Objective: To investigate the effect of ticlopidine on the hypercoagulability of nephrotic syndrome. Methods: Sixty-seven patients with nephrotic syndrome were randomly divided into two groups: 33 cases in the treatment group were treated with ticlopidine plus prednisone, and 34 cases in the control group were treated with prednisone alone. Urinary protein, serum albumin, serum creatinine , Cholesterol, low density lipoprotein, very low density lipoprotein, urinary fibrin degradation products, the maximum platelet aggregation rate and other indicators. Results: The serum albumin, cholesterol, low density lipoprotein, very low density lipoprotein, urinary fibrin degradation products and the maximum platelet aggregation rate in the treatment group were significantly different from those in the control group (P <0.05). Conclusion: Ticlopidine plus prednisone treatment of nephrotic syndrome hypercoagulable state was significantly better than prednisone alone