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1,5-戊二醛(通称Glutaraldehyde)为一种高效灭菌剂,其碱性溶液具有强烈的杀菌作用,对人体组织刺激性比甲醛低,但杀菌效能比甲醛强2～10倍。将欲消毒物品完全浸没在2％溶液中,一般15～20分钟即可达到完全消毒。目前除用于内窥镜器械、温室计、橡胶和塑料部件及不能用加热来消毒的设备外,还用于人工生物心脏瓣膜的消毒、固定及保存,具有很多优点,深受手术科室的欢迎。本文仅就戊二醛的理化性状、杀菌机理、杀菌作用和临床应用及其毒副反应等综述如下。
1,5-Glutaraldehyde (commonly known as Glutaraldehyde) is an efficient sterilizing agent. Its alkaline solution has a strong bactericidal effect. Its irritation to human tissues is lower than that of formaldehyde, but bactericidal effect is 2 to 10 times stronger than that of formaldehyde. To be disinfected items completely immersed in 2% solution, usually 15 to 20 minutes to achieve complete disinfection. In addition to the current endoscopic instruments, greenhouse meters, rubber and plastic parts and equipment can not be sterilized with heat, but also for the disinfection, fixation and preservation of artificial biological heart valves, has many advantages, by the surgical departments welcome . This article only on the physical and chemical properties of glutaraldehyde, bactericidal mechanism, bactericidal effect and clinical application and its side effects are summarized below.