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本文报告14例年轻何杰金氏病患者治疗后出现发作性中枢神经机能障碍,女12例,男2例,始发年龄在26～51岁,何杰金氏病病期为ⅡA10例,ⅡB、ⅢA、ⅢB 及ⅣB 各1例,结节硬化型12例,混合型2例。首次接受外放射治疗者13例,计主动脉旁10例、脾6例、肝门8例、骨盆及腹股沟2例、纵膈及颌下各1例,接受化疗者11例。14例均在缓解期出现神经症状,平均于完全缓解后31个月(4月～13年)。12例有某些脑血管病危险因素。所有患者均有突然开始和消失的发作,通常持续数秒至一小时,仅2例持续数日,1例长期持续。神经症状可分为3组:
This article reports 14 cases of Hodgkin’s disease patients after treatment of onset of central nervous system dysfunction, 12 females, 2 males, age at birth 26 to 51 years, Hodgkin’s disease stage Ⅱ A10 cases, Ⅱ B , ⅢA, ⅢB and ⅣB in 1 case, nodular sclerosis in 12 cases, mixed type in 2 cases. The first external radiotherapy in 13 cases, including 10 cases of aorta, spleen in 6 cases, hilar in 8 cases, pelvis and groin in 2 cases, mediastinal and submandibular in 1 case, 11 cases received chemotherapy. All 14 patients showed neurological symptoms during remission, averaging 31 months after complete remission (April to 13 years). Twelve patients had some risk factors for cerebrovascular disease. All patients had a sudden onset and disappearance of seizures, usually lasting from a few seconds to an hour, with only two continuing for days and one continuing for long. Neurological symptoms can be divided into 3 groups: