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目的研究血栓抽吸对急性心梗患者血白细胞介素-6(IL-6)、高敏C反应蛋白(hs-CRP)和N末端脑钠肽前体(NT-ProBNP)水平的影响。方法急性心梗患者57例,随机分为实验组[血栓抽吸+急诊经皮冠状动脉介入(PCI)治疗]和对照组(仅行急诊PCI治疗)。分别于入院即刻,急诊PCI术后72 h检测患者血IL-6、hs-CRP及NTProBNP的水平,对比分析两组患者上述指标间的差异。结果急诊PCI术后72 h实验组的IL-6、hs-CRP及NTProBNP水平显著低于对照组,差异有统计学意义(P<0.05)。结论血栓抽吸联合急诊PCI治疗能较单纯PCI治疗显著降低急性心梗患者血炎症因子及NT-ProBNP水平。
Objective To investigate the effects of thrombus aspiration on the levels of interleukin-6, hs-CRP and NT-ProBNP in patients with acute myocardial infarction. Methods Fifty-seven acute myocardial infarction patients were randomly divided into experimental group (thrombus aspiration + emergency percutaneous coronary intervention) and control group (only emergency PCI). The blood levels of IL-6, hs-CRP and NTProBNP were measured at 72 h after emergency PCI immediately after admission, and the differences between the above two indexes were compared. Results The levels of IL-6, hs-CRP and NTProBNP in the experimental group at 72 h after PCI were significantly lower than those in the control group (P <0.05). Conclusions Thrombus aspiration combined with emergency PCI can significantly reduce the levels of serum inflammatory cytokines and NT-ProBNP in patients with acute myocardial infarction compared with PCI alone.