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目的 :探讨经皮动脉导管药盒系统 (PCS)对晚期恶性肿瘤进行介入治疗的安全性、临床疗效、并发症及处理方法。方法 :经PCS化疗灌注治疗 14例晚期恶性肿瘤 (原发性肝癌 5例 ,肝转移癌 3例 ,肺癌 5例 ,胃癌 1例 )。药盒植入途径 :股动脉 11例 ,右锁骨下动脉 3例 ,右锁骨下静脉 1例。术后经药盒灌注化疗 2～ 4个疗程 ,每 3～ 6周为 1滚疗程。结果 :14例患者手术植入都获得成功 ,4例经右锁骨下动 静脉途径植入患者无气胸、血胸发生。肿瘤治疗有效率 (完全缓解CR +部分缓解PR)为 42 9%。有化疗药外渗 1例 ,本组未发生留置导管移位、导管堵塞、感染、出血等。结论 :经皮动脉植入PCS手术操作简便、安全 ,易为患者接受。PCS能长期留置 ,不影响患者日常生活 ,并可按照化疗药物的药代动力学特点对肿瘤进行化疗 ,是治疗晚期恶性肿瘤的一种良好技术和方法
Objective: To investigate the safety, clinical efficacy, complications and management of percutaneous arterial catheterization kit (PCS) for advanced malignancies. METHODS: Fourteen patients with advanced malignancies (primary liver cancer, 5 liver metastases, 3 liver cancer, 5 lung cancer, and 1 gastric cancer) were treated with PCS chemotherapy. Kit approach: femoral artery in 11 cases, right subclavian artery in 3 cases, right subclavian vein in 1 case. Postoperative chemotherapy infusion kit 2 to 4 courses, every 3 to 6 weeks for a rolling course. Results: All the 14 patients were successfully surgically implanted. There were no pneumothorax and hemothorax in 4 patients who were transplanted via the right subclavian artery and vein. The effective rate of tumor treatment (complete remission CR + partial remission PR) was 42 9%. A case of extravasation chemotherapy drugs in this group did not occur indwelling catheter displacement, catheter blockage, infection, bleeding and so on. Conclusion: Percutaneous arterial implantation of PCS is simple, safe and easy to be accepted by patients. PCS can be long-term indwelling, does not affect the daily life of patients, and in accordance with the pharmacokinetic characteristics of chemotherapy drugs for tumor chemotherapy is a good treatment for advanced malignant tumor technology and methods