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为探讨头颈部癌术前辅助治疗后肿瘤退缩区组织的DNA变化,应用流式细胞仪及常规病理方法,研究了30例口腔及咽喉部鳞癌术前辅助治疗后肿瘤组织及肿瘤退缩区组织的组织形态及DNA含量。结果表明,术前辅助化疗后肿瘤退缩区组织,虽然光镜下形态正常,但仍以DNA异倍体为主(28/30),增殖指数、G0/G1、G2/M的值,肿瘤退缩区与瘤体无明显差异,S期的比率较瘤体降低。因此,化疗后肿瘤退缩区在手术中若保留应持慎重态度。并对有关病例选择、标本取材等进行了讨论。
In order to investigate the DNA changes in tumor retraction zone after preoperative adjuvant treatment of head and neck cancer, flow cytometry and routine pathology were used to study the tumor tissue and tumor regression zone in 30 patients with oral and pharyngeal squamous cell carcinoma before surgery. Tissue organization and DNA content. The results showed that, after the preoperative adjuvant chemotherapy, the tissue in the tumor retraction zone was normal in DNA microscopy, but was still dominated by DNA aneuploidy (28/30), proliferation index, G0/G1, G2/M values, tumor regression There was no significant difference between the area and the tumor body, and the S-phase rate was lower than that of the tumor body. Therefore, the area of tumor regression after chemotherapy should be taken with caution if it remains during surgery. Case selection and specimen collection were discussed.