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高迁移率族蛋白B1(HMGB1)是一类进化高度保守的DNA结合蛋白,广泛存在于真核细胞内。HMGB1可通过活化细胞的主动分泌或细胞坏死、损伤等被动释放至细胞外,通过与Toll样受体、晚期糖基化终末产物受体等结合,激活相应的信号转导通路,参与多种疾病的发生、发展。近年来研究显示,细胞外的HMGB1作为炎性介质在组织器官缺血损伤或缺血/再灌注损伤(IRI)中发挥重要作用,对HMGB1的干预治疗有可能成为防治IRI的新靶标。
High-mobility group protein B1 (HMGB1) is a class of evolutionarily highly conserved DNA-binding proteins that are found extensively in eukaryotic cells. HMGB1 can be passively released to the outside of the cell through active secretion or cell necrosis of activated cells, injury and the like, activate the corresponding signal transduction pathway by binding to Toll-like receptors, advanced glycation end-products receptors and the like, The occurrence and development of disease. In recent years, studies have shown that extracellular HMGB1 as an inflammatory mediator plays an important role in tissue ischemia injury or ischemia / reperfusion injury (IRI), the intervention of HMGB1 may become a new target of prevention and treatment of IRI.