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作者从７３例根尖周炎和５７例成年人牙周炎患者临床标本中，分离获得３０种２１０株无芽胞厌氧菌，检出率为９０．０％。替硝唑对８个属２０８株厌氧菌的ＭＩＣ５０和ＭＩＣ９０明显低于甲硝唑和乙酰螺旋霉素。替硝唑体外抗革兰氏阴性无芽胞厌氧菌的作用较氯林可霉素为强，但对革兰氏阳性无芽胞厌氧菌的抗菌效果不如氯林可霉素。替硝唑和甲硝唑体内杀厌氧菌率分别为８９．６％和６２．３％，治疗根尖周炎的有效率分别为８５．４％和４４．０％，治疗成年人牙周炎的有效率分别为７６．９％和４４．４％（均Ｐ＜０．０５）。实验结果表明，替硝唑有较强的体内、外抗厌氧菌作用。
From 73 cases of periapical periodontitis and 57 adult patients with periodontitis, 30 kinds of 210 non-spore-forming anaerobes were isolated and the detection rate was 90.0%. The MIC50 and MIC90 of tinidazole to 208 anaerobe strains of 8 genera were significantly lower than those of metronidazole and acetylspiramycin. The effect of tinidazole against Gram-negative non-spore-forming anaerobes was stronger than that of clindamycin, but not as good as clindamycin for Gram-positive non-spore-forming anaerobes. Tinidazole and metronidazole in vivo kill anaerobic bacteria were 89.6% and 62.3%, the effective rate of treatment of apical periodontitis were 85.4% and 44.0%, respectively, the treatment of adult periodontal The effective rates of inflammation were 76.9% and 44.4% (all P <0.05). The experimental results show that tinidazole has strong in vivo and external anti-anaerobic bacteria.