论文部分内容阅读
目的分析三维适形放射治疗联合同步化疗治疗食管癌的临床效果。方法选取2010年1月至2012年1月间收治的62例食管癌患者,随机分为观察组和对照组,观察组32例患者采用三维适形放射治疗联合同步化疗治疗方案,对照组30例患者采用单独放射治疗方案,观察两组患者近期疗效、生存率和不良反应。结果观察组近期疗效为81.2%,高于对照组的63.3%,差异有统计学意义(P<0.05),观察组、对照组的8个月生存率分别为62.5%和56.7%,差异无统计学意义(P>0.05),16个月生存率分别为46.9%和30.0%,差异有统计学意义(P<0.05)。不良反应主要为放射性食管炎、恶心呕吐、白细胞减少等,且观察组高于对照组。结论三维适形放射治疗联合同步化疗治疗食管癌可提高近期疗效和生存率,虽然不良反应增加,但患者可以耐受。
Objective To analyze the clinical effect of three-dimensional conformal radiotherapy combined with concurrent chemotherapy in the treatment of esophageal cancer. Methods Sixty-two patients with esophageal cancer who were admitted between January 2010 and January 2012 were randomly divided into observation group and control group. Thirty-two patients in observation group were treated with three-dimensional conformal radiotherapy combined with concurrent chemotherapy, and 30 in control group Patients with a separate radiotherapy program to observe the two groups of patients with short-term efficacy, survival and adverse reactions. Results The curative effect in observation group was 81.2%, higher than that in control group (63.3%), the difference was statistically significant (P <0.05). The 8-month survival rates in observation group and control group were 62.5% and 56.7% respectively, with no statistical difference (P> 0.05). The 16-month survival rates were 46.9% and 30.0% respectively, with statistical significance (P <0.05). Adverse reactions are mainly esophagitis, nausea and vomiting, leukopenia, etc., and the observation group was higher than the control group. Conclusion Three-dimensional conformal radiotherapy combined with concurrent chemotherapy in the treatment of esophageal cancer can improve the short-term efficacy and survival rate, although the adverse reactions increased, but patients can tolerate.