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采用高效液相色谱－荧光法测定氢溴酸右美沙芬血药浓度，研究了８名健康志愿者随机交叉单剂量给予滴鼻液７．５ｍｇ滴鼻或片剂６０ｍｇ口眼的药代动力学。结果表明，两种剂型经不同途径给药的药物体内过程符合线性二房室模型特征。小剂量滴鼻液经鼻腔粘膜吸收，因其避免了肝脏的代谢，故与口服片剂比较，具有相对吸收迅速，生物利用度较高的药代动力学特点。提示该滴鼻液系一符合临床应用要求的镇咳新剂型。
The plasma concentration of dextromethorphan hydrobromide was determined by HPLC-fluorescence method. The pharmacokinetics of dextromethorphan hydrobromide in eight healthy volunteers were studied in a randomized crossover single dose of nasal drops of 7.5 mg intranasally or 60 mg of oral tablets . The results showed that the in vivo process of the two formulations administered by different routes conformed to the linear two-compartment model characteristics. Small doses of nasal fluid absorbed through the nasal mucosa, because it avoids the liver metabolism, it is compared with oral tablets, with relatively rapid absorption, high bioavailability of the pharmacokinetic characteristics. Tip of the nasal drops of a line of clinical application requirements of new antitussive formulations.