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本文探讨了５／６肾切除术后慢性肾衰大鼠残肾纤维化的发生机理，发现术后１２０天，在残肾单个核炎性细胞浸润、残肾显著纤维化和肾功能损害的同时，残肾脂质过氧化物含量显著升高，抗氧化机制功能显著下降，钠钾ＡＴＰ酶活力显著下降，周围血单个核细胞内游离钙浓度显著升高，单个核细胞培养上清白介素－１活性增高。而摄入大量维生素Ｅ的大鼠，上述各指标有不同程度的改善，残肾纤维化显著减轻。提示残肾纤维化可能与单个核白细胞内游离钙浓度升高，进而产生白介素－１增多有关。
This article explores the 5/6 nephrectomy in rats with chronic renal failure residual renal fibrosis pathogenesis and found that 120 days after residual renal single nucleus inflammatory cell infiltration, residual renal significant fibrosis and renal dysfunction at the same time , The residual renal lipid peroxide content was significantly increased, the anti-oxidative mechanism significantly decreased, Na-K ATPase activity decreased significantly, peripheral blood mononuclear cells within the free calcium concentration was significantly increased mononuclear cell culture supernatant interleukin- 1 activity increased. The intake of a large number of vitamin E in rats, the above indicators have varying degrees of improvement, significant reduction of residual renal fibrosis. Tip remnant fibrosis may be associated with an increase in intracellular free calcium concentration in mononuclear cells, which in turn lead to increased interleukin-1.