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本文比较了正常男子(Ⅰ组)、各种无精症患者(包括棉酚服用者。Ⅱ组)、原因不明的无精症者(Ⅲ组)以及Klinefelter 综合征患者(Ⅳ)血浆中FSH、LH、PRL、T、E_2和F 的变化。结果所有无精症患者的平均FSH、LH 水平明显高于Ⅰ组(P<0.001),但PRL、T、E_2及F 的平均值与Ⅰ组无区别(P>0.05)Ⅱ、Ⅲ组患者FSH 水平升高者与正常者各为50%,其余各组明显高于正常。Ⅲ组的LH 及T/LH 比值仍在正常范围内,但T、E_2及F 的平均值升高,PRL 降低;其余各组LH 与FSH 平行升高,T 及T/LH比值明显低于Ⅰ组(P<0.001),但E_2、F 及PRL 则在正常范围内。本实验证实,避孕剂量的棉酚并不损害睾丸合成T 的功能。FSH 过高说明生精上皮损害过度。本文还提出了一些控制棉酚用量的客观指标。
This article compared the plasma levels of FSH, normotensives in patients with azoospermia (including gossypol users, group Ⅱ), patients with unexplained azoospermia (group Ⅲ) and patients with Klinefelter syndrome (Ⅳ) LH, PRL, T, E_2 and F changes. Results The average level of FSH and LH in all patients with azoospermia was significantly higher than that in group Ⅰ (P <0.001), but the average values of PRL, T, E_2 and F were not different from those in group Ⅰ (P> 0.05) The level of those with normal and 50% of each, the remaining groups were significantly higher than normal. The LH and T / LH ratio in group Ⅲ were still within the normal range, but the average values of T, E_2 and F increased and PRL decreased. The other groups increased in parallel with FSH and the T and T / LH ratios were significantly lower than those in Ⅰ Group (P <0.001), but E_2, F and PRL were in the normal range. This experiment confirmed that the contraceptive dose of gossypol does not impair the function of testes to synthesize T. FSH is too high to explain excessive damage to the germinal epithelium. This article also put forward some objective indicators to control gossypol consumption.