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Duchenne肌营养不良(DMD)也许是人类中最常见的X-连锁疾病,每4,000个男性中就有一个DMD患者,该病由女性携带者传递.患病男子的姐妹有50%的风险为携带者,显然约70%携带者的血清肌酸激酶水平升高,但至今仍无可靠方法进行产前诊断或检测女性携带者.DMD座位在X染色体短臂的中部(Xp21),过去两年中已发现其附近的两个DND探针,可惜位置还嫌太远.最近Monaco等成功地克隆了一个DNA片段,它可检测DMD基因本身或附近
Duchenne muscular dystrophy (DMD) may be the most common X-linked disease in humans, with one out of every 4,000 men with DMD, which is transmitted by female carriers Sister sick men have a 50% , Apparently about 70% of carriers of serum creatine kinase levels, but so far there is no reliable method for prenatal diagnosis or detection of female carriers .DMD seat in the X chromosome short arm in the middle (Xp21), the past two years It has been found that two DND probes in the vicinity of the DMD gene have been found too far.Micaco recently successfully cloned a DNA fragment that can detect the DMD gene itself or in the vicinity