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紫外线照射皮肤可产生游离基团,早期的红斑反应和血管渗透性增加,至少部分是由于活化前列腺素合成所致。局部应用消炎痛可抑制紫外线照射皮肤产生前列腺素.减轻红斑反应。丁基羟基甲苯是一种抗氧剂,当鼠摄入后也可减轻皮肤对紫外线的反应。该化合物能直接与游离基团相互作用,故认为其它基团清除剂也可能有防护作用,因甲硫噻唑(他巴唑)可与羟基相互作用,并抑制前列腺素E_2合成。为此作者对硫脲药物减轻紫外线红斑的作用进行了试验,试验以汞灯为紫外线光源,在4名自愿者身上进行。试验用的硫脲药物为新鲜配制饱和甲硫噻唑或2-巯基苯骈咪唑n-丁醇溶液,并以消炎痛的相同溶液作为对照,在紫外线照射前后,或仅在照射后用于试验处皮肤,照射后经6和24小时观察反应。结
Irradiation of the skin with UV light produces free radicals, an increase in early erythema reaction and increased vascular permeability, at least in part due to activated prostaglandin synthesis. Topical application of indomethacin can inhibit ultraviolet radiation to produce prostaglandin skin. Reduce the reaction. Butylated hydroxytoluene is an antioxidant that reduces the skin’s reaction to ultraviolet light when taken in by rats. The compound can interact directly with free radicals and therefore it is thought that other group scavengers may also have a protective effect because methothiazole (methimazole) interacts with hydroxyl groups and inhibits prostaglandin E 2 synthesis. To this end the author of the thiourea drugs to reduce the role of UVA erythema were tested with mercury lamp as the UV light source, carried out in four volunteers. The test thiourea drugs were freshly prepared saturated methylthio thiazole or 2-mercaptobenzimidazole n-butanol solution, and the same solution of indomethacin as a control, before or after UV irradiation, or only after irradiation for the test The skin was observed after 6 and 24 hours after irradiation. Knot