急性幕上性脑出血患者脑水肿体积与高迁移率族蛋白B1的关系

• 作 者: 李新玲 黄怀宇 朱连海 丁莉 陆珍辉 汪志峰
• 机 构: 江苏南通大学第二附属医院神经内科,江苏南通大学第二附属医院神经外科,
• 出 处: 卒中与神经疾病
• 发表日期: 2016年05期
• 关键词: 脑出血早期 高迁移率族蛋白 脑水肿 血肿量 自发性脑出血 脑出血者 继发性脑损伤 肿瘤坏死因子 基线资料 金属蛋白

目的探讨脑出血后高迁移率族蛋白B1(high mobility group protein B1,HMGB1)水平的变化及其与脑出血后继发性脑水肿的关系。方法收集152例幕上性脑出血患者的入院各基线资料及发病24 h时的HMGB1水平和发病后3或4 d复查头颅CT显示的相对水肿体积。结果初入院的HMGBl水平要显著高于对照组(P<0.05),且24 h患者HMGBl水平与第3或4 d CT复查显示的相对水肿体积呈正相关(r=0.87,P=0.001)。结论脑出血后HMGBl水平显著升高,且与脑水肿体积进展程度呈正相关。

Objective To investigate the changes of high mobility group protein B1 (HMGB1) after cerebral hemorrhage and its relationship with secondary cerebral edema after intracerebral hemorrhage. Methods The baseline data of 152 patients with supratentorial intracerebral hemorrhage and the HMGB1 level at 24 h after onset were collected and the relative edema volume showed by head CT examination at 3 or 4 d after onset. Results The level of HMGB1 at admission was significantly higher than that of the control group (P <0.05). The level of HMGB1 in 24 h was positively correlated with the relative edema volume at the third or fourth day after CT examination (r = 0.87, P = 0.001). Conclusion The level of HMGB1 in cerebral hemorrhage is significantly increased and positively correlated with the volume of brain edema.