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目的探讨术前桡动脉灌注化疗在Ⅱb-Ⅲb期乳腺癌治疗中的意义。方法 315例Ⅱb-Ⅲb期乳腺癌随机分为A组(术前经桡动脉CAP方案灌注化疗)和B组(术前无化疗),评定A组的临床疗效与病理组织学反应。对比两组的5年存活率及无病存活率。检测两组肿瘤细胞的细胞凋亡指数。结果 A组乳腺肿瘤与腋淋巴结临床有效率为80.2%与77.6%组织学反应显效率92.6%。A组和B组的5年存活率为77.8%和63.4%,5年无病存活率为72.2%和56.9%;细胞凋亡指数为19.37±6.49和9.2±5.04。差异有统计学意义(P〈0.05)结论术前桡动脉灌注化疗能有效地提高对乳腺肿瘤及腋窝淋巴结的局部临床控制率,提高远期疗效。
Objective To investigate the significance of preoperative radial artery infusion chemotherapy in the treatment of stage Ⅱb-Ⅲb breast cancer. Methods A total of 315 patients with stage Ⅱb-Ⅲb breast cancer were randomly divided into group A (premedication of radial arterial infusion with CAP) and group B (no chemotherapy before operation). The clinical efficacy and histopathological response in group A were evaluated. Five-year survival rate and disease-free survival rate were compared between the two groups. The apoptosis index of tumor cells in two groups was detected. Results The clinical effective rate of breast cancer and axillary lymph node in Group A was 80.2% and 77.6% respectively. The effective rate was 92.6%. The 5-year survival rates of group A and group B were 77.8% and 63.4%, respectively, and the five-year disease-free survival rates were 72.2% and 56.9%. The apoptosis index was 19.37 ± 6.49 and 9.2 ± 5.04 respectively. The difference was statistically significant (P <0.05) Conclusions Radial artery infusion chemotherapy before operation can effectively improve the local clinical control rate on breast tumors and axillary lymph nodes, and improve long-term efficacy.