【摘 要】
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Objective: The aim of this study was to investigate the ef ect on Akt and PTEN expression and the mechanism of proliferation and apoptosis of melanoma B16 cel s
【机 构】
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Biochemistry and Molecular Biology Laboratory,Department of Radiotherapy
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Objective: The aim of this study was to investigate the ef ect on Akt and PTEN expression and the mechanism of proliferation and apoptosis of melanoma B16 cel s treated with chamaejasme extract. Methods: The expressions of Akt and PTEN of B16 cel s treated with dif erent concentrations of chamaejasme extract were detected with immunohistochemical method, cel apoptosis index (AI) was calculated with in situ labeling method. Results: Akt expressions of B16 cel s treated with dif erent concentrations of chamaejasme extract were significantly lower than the control group, while the PTEN expres-sions significantly up-regulated, and the ef ects appeared to be dose-related (P < 0.05). The Akt/AI of B16 cel s treated with dif erent concentrations of chamaejasme extract was significantly lower than the control group, al the parameters had ex-tremely dif erence (F = 24.58, P < 0.05). Conclusion: Chamaejasme extract can inhibit proliferation and induce apoptosis of malignant melanoma B16 cel s by down-regulating the expression of Akt and up-regulating the expression of PTEN.
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