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本文所研究的片剂有苯乙双胍,氯磺丙脲,克罗米芬枸橼酸盐,氨茶碱,安定醋氨酚以及速尿。试验用的装置为将USP 所用转篮,改为5.5cm 高(原为3.66cm)256目筛(代替40目筛),使用的人工胃液和人工肠液的pH 分别为1.2和7.5。取1000ml 圆筒容器加900ml 溶媒,升温,维持在37°±0.5°。将一片剂置转篮中(排除表面的任何气泡)立即以60rpm 旋转。在预定检测时间,从溶媒表面和转篮顶部间的中间区抽
The tablets studied in this article are phenformin, chlorpropamide, clomiphene citrate, aminophylline, diazepam and furosemide. The device used for the test was to change the basket used in the USP to a 256-mesh sieve (instead of a 40-mesh sieve) of 5.5 cm in height (originally 3.66 cm). The artificial gastric juice and artificial intestinal juice used had a pH of 1.2 and 7.5, respectively. Take 1000ml cylindrical container plus 900ml solvent, warming, maintained at 37 ° ± 0.5 °. Place one tablet in the basket (excluding any air bubbles on the surface) and immediately rotate at 60 rpm. At the scheduled test time, draw from the middle of the media surface and the top of the basket