论文部分内容阅读
目的探讨替米沙坦对实验性动脉粥样硬化兔肝脏组织中Se含量的变化。方法用高脂饮食复制兔动脉粥样硬化,然后给予替米沙坦建立治疗组模型,获取肝脏,用硝酸、过氧化氢混合液微波消解样品,采用原子荧光光谱法测定肝脏组织中Se的含量。结果正常组饲料和高脂组饲料Se含量分别为0.21、0.64mg/Kg,正常组、高脂组和治疗组Se在肝脏组织中含量分别为3.3075mg/Kg、2.1391mg/Kg和1.7800mg/Kg。结论给予替米沙坦治疗后,替米沙坦治疗组的Se平均含量比高脂组的平均含量下降37.36%,替米沙坦可能对Se的吸收有明显抑制作用。
Objective To investigate the changes of Se content in the liver tissue of experimental atherosclerosis rabbits treated with telmisartan. Methods Rabbit model of atherosclerosis was established by high-fat diet, and then treated with telmisartan to establish the treatment group. The liver was harvested and the samples were digested with nitric acid and hydrogen peroxide. The content of Se in the liver tissue was measured by atomic fluorescence spectrometry . Results The contents of Se in the normal diet and the high-fat diet were 0.21 and 0.64 mg / Kg, respectively. The levels of Se in the normal group, the high-fat diet group and the treated group were 3.3075mg / Kg, 2.1391mg / Kg and 1.7800mg / Kg. Conclusion After treatment with telmisartan, the average content of Se in the treatment group decreased 37.36% compared with that in the high-fat group, and telmisartan may have a significant inhibitory effect on the absorption of Se.