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目的用携带ｃａｇＡ基因的Ｈｐ成功感染ＢＡＬＢ／ｃ裸鼠。方法分别采用ｃａｇＡ基因阳性和阴性的具有较强动力的新鲜Ｈｐ分离菌株，通过灌胃方式感染ＢＡＬＢ／ｃ裸鼠，感染后４周和８周分两批处死，进行微生物学和病理组织学检查。结果灌喂８周后，ｃａｇＡ＋实验组和ｃａｇＡ－实验组均成功定植Ｈｐ（１６／１６）；ｃａｇＡ＋组胃粘膜表现明显炎症及坏死病变，而ｃａｇＡ－组仅有轻微炎症发生。结论建立典型的Ｈｐ动物感染模型应选择ｃａｇＡ＋菌株。
Objective To successfully infect BALB / c nude mice with Hp carrying cagA gene. Methods BALB / c nude mice were infected with fresh Hp isolates positive and negative by cagA gene respectively. The BALB / c nude mice were infected by gavage. The mice were sacrificed in two batches at 4 weeks and 8 weeks after infection. Microbiological and histopathological examination . Results After 8 weeks of induction, Hp (16/16) colonies were successfully established in both cagA + and cagA-treated groups. Gastric mucosa showed obvious inflammatory and necrotic lesions in cagA + group, while only mild inflammation occurred in cagA + group. Conclusion To establish a typical Hp animal model of infection, cagA + strains should be selected.