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内皮祖细胞(endothelial progenitor cell,EPC)是存在于骨髓和循环外周血的祖细胞亚群,具有在体内外分化为成熟内皮细胞的能力,参与血管发生和血管稳态。恶性肿瘤细胞产生多种细胞因子,使骨髓中的EPC动员至外周血,并募集到肿瘤组织的血管床,参与肿瘤血管生成、肿瘤生长和转移。外周血EPC水平与肿瘤的体积、抗新生血管治疗的反应性和预后等密切相关,因此EPC可作为肿瘤血管新生的生物标记物。EPC还可作为靶向肿瘤的细胞载体负载自杀基因、毒素或药物,为抗肿瘤治疗提供了新的途径。
Endothelial progenitor cells (EPCs) are a subset of progenitor cells that exist in bone marrow and circulating peripheral blood. They are capable of differentiating into mature endothelial cells in vitro and in vivo and are involved in angiogenesis and vascular homeostasis. Malignant tumor cells produce a variety of cytokines that mobilize EPCs from the bone marrow into the peripheral blood and recruit vascular beds into the tumor tissue to participate in tumor angiogenesis, tumor growth and metastasis. EPC levels in peripheral blood are closely related to tumor volume, anti-angiogenic reactivity and prognosis, so EPC can be used as a biomarker for tumor angiogenesis. EPC can also act as a tumor-targeting cell carrier to carry suicide genes, toxins or drugs and provide a new way for anti-tumor therapy.