论文部分内容阅读
本文旨在研究左旋咪唑对亚硝胺类致食管癌作用的影响。Wistar大鼠82只，以甲基戊基亚硝胺诱发食管癌前病变，分别预防性给于左旋咪唑、太洛龙。经105天后，检测食管癌前病变发生率，用高效液相色谱法测定血清MANA含量。结果显示左旋咪唑和太洛龙均有降低食管癌前病变发生率及血清MANA作用，但左旋咪唑使大鼠体重增长正常，而太洛龙则使其变慢，提示二者具有相似地预防亚硝胺类致食管癌作用，并且左旋咪唑优于太洛龙。
This article aims to investigate the effects of levamisole on nitrosamine-induced esophageal cancer. Eighty-eight Wistar rats were treated with methyl amyl nitrosamine to induce esophageal precancerous lesions. They were given preventively to levamisole and taroton. After 105 days, the incidence of esophageal precancerous lesions was detected and the serum MANA content was determined by high performance liquid chromatography. The results showed that both levamisole and teracolon reduced the incidence of esophageal precancerous lesions and serum MANA, but levamisole normalized the body weight in rats, and taroton made it slower, suggesting that both have a similar preventive effect. Nitroamines act as esophageal cancers, and levamisole is superior to talonolone.