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目的对照研究50例卵巢癌的腹腔化疗和全身静脉化疗,观察并评价2种治疗方法的近期疗效、毒性反应和远期疗效。方法随机分为腹腔化疗组(腹腔组)26例和静脉组(对照组)24例,记录观察毒副反应,随访患者并计算生存期。结果近期疗效2组相仿,毒副反应中恶心呕吐、骨髓抑制症状,腹腔组明显低于对照组,而腹胀腹痛则腹腔组与对照组无差异,肝肾功能损害2组差异有显著性;腹腔组中位生存期和1年生存率显著高于对照组。结论卵巢恶性肿瘤患者进行腹腔化疗可提高生存质量,延长生存期。
Objective To study the efficacy of peritoneal chemotherapy and systemic intravenous chemotherapy in 50 patients with ovarian cancer and to observe and evaluate the short-term curative effect, toxicity and long-term curative effect of the two treatment methods. Methods Twenty-six patients in the intraperitoneal chemotherapy group (intraperitoneal group) and 24 in the intravenous group (control group) were randomly divided into two groups. Toxic and side effects were recorded and the patients were followed up and the survival time was calculated. Results The two groups had similar effects in the short term. Nausea and vomiting, bone marrow suppression and abdominal cavity were significantly lower than those in the control group. There was no difference between the abdominal cavity and abdominal cavity in control group, liver and kidney dysfunction were significant difference between the two groups. The median survival time and 1-year survival rate were significantly higher in the control group. Conclusion Intraperitoneal chemotherapy in patients with ovarian cancer can improve the quality of life and prolong survival.