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极性双官能团化合物如1,2及1,3二醇,α-及β-羟基酸、1,2及1,3羟基胺等常制成苯基硼盐酸衍生物后用GLC分析,衍生化反应在水存在下能瞬间发生:因此可以在柱上进行。本文以眠尔通(2-甲基-2丙基丙烷-1,3二醇-二氨基甲酸酯)为例说明之。眠尔通以强碱催化水解至2-甲基-二丙基丙烷-1,3二醇(MPPD),然后由甲基-叔丁基醚(MTBE)提取,在甲醇-水(2+1)中与苯基硼酸(PBA)衍生化,以甲基眠尔通[二甲基2-仲丁基丙烷-1,3二醇(MBPD)二氨基
Polar bifunctional compounds such as 1,2 and 1,3-diol, α- and β-hydroxy acids, 1,2 and 1,3-hydroxylamine and other compounds often produced phenylboronic acid using GLC analysis, derivatization The reaction can take place instantaneously in the presence of water: it can therefore be carried out on a column. In this article, Mellitus (2-methyl-2-propylpropane-1,3-diol - dicarbamate) as an example. Mesophamidase catalyzed hydrolysis to 2-methyl-dipropylpropane-1,3-diol (MPPD) with strong base followed by extraction with methyl-tert-butyl ether (MTBE) ) With phenyl boronic acid (PBA) derivatization, methyl methylthionate [dimethyl 2-sec-butyl propane-1,3 diol (MBPD) diamino