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总血清钙在正常范围内的高水平与心血管疾病风险增高相关。因此,有必要对具有生理学活性的钙的离子化形式是否也是心血管疾病的一个危险因素作出评价。在一项健康调查中,对974例参与者的血清离子钙和不同的心血管疾病危险因素均予以测量和随访。参试者均为缺血性心脏病和广义的心血管疾病患者。将血清离子钙在最高1/5水平的参与者与较低的4/5参与者相比较。研究结果显示,在单变量分析中,血清离子钙在最高1/5水平的参与者缺血性心脏病和心血管疾病的危险增加。这种增加的危险性在一项包含性别和心血管混杂因素的Cox比例风险分析中不复存在。在一项男性和缺血性心脏病独立相关分析的结果仍然没有统计学意义。研究认为,对于男女总体而言,血清离子钙在高1/5水平并不是缺血性心脏病和心血管疾病的发展中一个危险因素,但是血清离子钙在高1/5水平的男性与低4/5者男性相比,观察到缺血性心脏病的危险性似乎有增高的趋势。
The high level of total serum calcium in the normal range is associated with an increased risk of cardiovascular disease. Therefore, it is necessary to evaluate whether the ionized form of physiologically active calcium is also a risk factor for cardiovascular disease. In a health survey, serum ionized calcium and various cardiovascular risk factors for 974 participants were measured and followed up. The participants were all ischemic heart disease and generalized cardiovascular disease. Participants of serum ionized calcium at up to 1/5 level were compared to the lower 4/5 participants. The results showed that in univariate analysis, serum ionized calcium was associated with an increased risk of ischemic heart disease and cardiovascular disease in up to one-fifth of participants. This increased risk no longer exists in a Cox proportional hazards analysis that includes gender and cardiovascular confounders. The results of an independent correlation analysis between a male and an ischemic heart disease were still not statistically significant. Studies suggest that serum ionized calcium is not a risk factor for the development of ischemic heart disease and cardiovascular disease at a high 1/5 level for both men and women overall, but serum ionized calcium is significantly lower in men at 1 in 5 levels 4/5 compared to men, observed the risk of ischemic heart disease appears to be increasing trend.