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目的：探讨环孢霉素Ａ（ＣｓＡ）逆转复发难治性急性白血病的临床意义及推广价值。方法：采用免疫组织化学ＡＢＣ法，ｐ１７０单抗ＪＳＢ－１检测复发难治性白血病的ｐ１７０表达，并对阳性患者随机分组，用ＣｓＡ加联合化疗进行逆转多药耐药研究，同时采用高效液相色谱法检测ＣｓＡ血药浓度，探讨ＣｓＡ血药浓度和逆转疗效间的关系。结果：ｐ１７０在复发难治性白血病中有高表达；ＣｓＡ有较好逆转复发难治性白血病多药耐药的作用（Ｐ＜０．０５）；ＣｓＡ血药浓度和逆转疗效呈正相关。结论：ＣｓＡ可能成为安全有效的逆转药物，在治疗复发难治性ＡＬ中有较大临床意义及推广价值。
Objective: To investigate the clinical significance and popularization value of cyclosporin A (CsA) in reversing relapsed and refractory acute leukemia. Methods: The expression of p170 in relapsed and refractory leukemia was detected by immunohistochemistry ABC method and p170 monoclonal antibody JSB-1. Positive patients were randomly divided into groups. CsA plus combination chemotherapy was used to reverse multidrug resistance and high-performance liquid chromatography was used. Chromatography was used to determine the plasma concentration of CsA, and the relationship between plasma concentration of CsA and reversal efficacy was explored. Results: p170 was highly expressed in relapsed and refractory leukemia; CsA had better reversal of multidrug resistance of relapsed and refractory leukemia (P<0.05); CsA plasma concentration was positively correlated with reversal of curative effect. Conclusion: CsA may be a safe and effective reversal drug. It has great clinical significance and popularization value in the treatment of relapsed and refractory AL.