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目的比较4种短效达必佳方案在诱发排卵中的效果。方法2000~2001年华中科技大学同济医学院附属同济医院采用以下4种短效达必佳方案,比较其在诱发排卵中的效果方案1月经第2天开始用达必佳01mg皮下注射,直至注射HCG时止;方案2上次月经第21天开始皮下注射达必佳01mg共7d;方案3上次月经的21天开始隔日1次皮下注射达必佳01mg直至注射HCG时止;方案4上次月经第21天开始每日皮下注射达必佳005mg直至注射HCG时止。结果4种方案的总取消率差异无显著意义(P>005),方案3的妊娠率和继续妊娠率最高(429%,356%),但与方案4比较差异无显著性意义(389%,311%)(P>005),方案2的妊娠率低于方案3和方案4,而且流产率较高,校正了不同治疗时间的差别后,妊娠率和继续妊娠率仍低于方案3和方案4;方案1的效果最差,妊娠率低而流产率高。结论月经第21天隔日皮下注射达必佳0.1mg进行垂体降调节效果最好,使用方便,值得推广。
Objective To compare the efficacy of 4 short-acting up to the best in induced ovulation. Methods From 2000 to 2001, Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology adopted the following four kinds of short-acting Dapi Jia scheme to compare their effects on ovulation induction. The first day of menstruation began with subcutaneous injection of daubicin 01 mg on the second day of menstruation until injection HCG only; program 2 menstruation began on the 21st day of subcutaneous injection of daopiperam 01mg a total of 7d; program 3 from the last menstrual 21 days every other day 1 subcutaneous injection of daopiperamine 01mg until the injection of HCG; On the 21st day of menstruation began to subcutaneous daily dabigatran 005mg until the injection of HCG only. Results There was no significant difference in the total cancellation rate among the four schemes (P> 005). The highest pregnancy rate and continued pregnancy rate were 429% and 356% in program 3, but no significant difference compared with program 4 (389% 311%) (P> 005). The pregnancy rate of scheme 2 was lower than that of scheme 3 and 4, and the abortion rate was high. After correcting the difference of different treatment time, the pregnancy rate and continuing pregnancy rate were still lower than those of scheme 3 and scheme 4; Scenario 1 is the worst, pregnancy rate is low and abortion rate is high. Conclusion Menstruation on the 21st day every other day subcutaneous injection of 0.1mg Daipi best pituitary lowering effect of the best, easy to use, it is worth promoting.