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本病的化学治疗历史虽已有60余年,但目前所用药物仍难令人满意。发展新药的主要困难之一是找不到适合于感染这种寄生虫的小动物模型供药物筛选之用,因为丝虫的宿主选择性极其严格,感染人的班氏丝虫和马来丝虫都不感染实验动物,目前只能用和人间接有关的虫种进行药物筛选工作。(摘者按。国内外已成功地用长爪沙鼠感染马来丝虫。)
Although the history of chemotherapy for this disease has been more than 60 years, the drugs used at present are still not satisfactory. One of the major difficulties in developing new drugs is that no small animal model suitable for infecting such parasites can be found for drug screening because of the extremely stringent host selectivity of filarial infections, All do not infect experimental animals, so far the drug screening work can only be done with insects indirectly related to human beings. (Picked by. Domestic and foreign male gerbils have been successfully infected with gerbils.)