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目的 研究早期康复干预对新生儿缺氧缺血性脑病 (HIE)的临床疗效。对象 临床诊断HIE的足月儿4 1例 ,随机分为干预组 (2 1例 )和非干预组 (2 0例 )。方法 干预组接受早期训练 ,定期随访以CDCC婴幼儿智能发育检查量表进行智能发育评估 ,根据评估的结果进一步指导干预 ,在 12～ 18个月对所有患儿以Gesell发育诊断量表进行智能发育最终评估 ,同时进行常规体格检查和育儿指导。结果 3月龄、6月龄时干预组CDCC量表的智力发育指数均高于非干预组 (P <0 0 5 ) ;两组心理运动发育指数无显著性差异 (P >0 0 5 )。 1岁时Gesell智能检查干预组总发育商 (DQ)和言语能DQ高于非干预组 (P <0 0 1) ;而两组动作能、应物能、应人能DQ无显著性差异 (P >0 0 5 )。结论 对HIE患儿进行早期干预可改善预后。
Objective To study the clinical effect of early rehabilitation intervention on neonatal hypoxic-ischemic encephalopathy (HIE). Subjects were enrolled in this study. Twenty-one full-term infants with clinical diagnosis of HIE were randomly divided into intervention group (n = 21) and non-intervention group (n = 20). Methods The intervention group received early training and was followed up regularly to assess the intelligence development of the CDCC infant mental development checklist. According to the results of the evaluation, further intervention was conducted and all children were intelligently developed with the Gesell developmental diagnostic scale from 12 to 18 months Final assessment, while conducting routine physical examination and parenting guidance. Results The mental development index of CDCC scale in intervention group was significantly higher than that in non-intervention group at 3-month-old and 6-month-old (P <0.05). There was no significant difference between the two groups in psychomotor development index (P> 0.05). At 1 year of age, DQ and DQ of the intervention group were significantly higher than those of the non-intervention group (P <0.01). However, no significant difference was found in DQ and DQ between the two groups P> 0 0 5). Conclusion Early intervention in children with HIE can improve the prognosis.