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对１０例髌股关节骨关节病患者病变关节软骨、软骨下骨及滑膜组织的超微结构进行了研究。实验结果表明：（１）髌股关节骨关节病患者关节软骨、软骨下骨及滑膜组织均呈不同程度超微结构变化。（２）髌股关节内侧间隙呈Ⅰ～Ⅱ级退变，主要由于该部位关节软骨缺乏相应的载荷刺激所致废用性退变；外侧间隙呈Ⅲ～Ⅳ级退变，主要由于股四头肌内侧头萎缩，髌骨半脱位，导致局部应力集中，关节面不断撞击、磨损所致。（３）软骨下骨呈强烈硬化趋势，其改变可先于、晚于或平行于关节软骨改变，变化规律与载荷性质有关。（４）Ⅰ～Ⅱ级软骨退变的修复组织更接近于正常软骨组织，而Ⅲ～Ⅳ级退变的修复组织则更像纤维软骨组织，两者差异可能由于其修复组织的来源不同所致。（５）滑膜组织的改变则为继发于关节软骨退变的非特异性炎性反应，并可进一步加重前者退变。（６）临床对Ⅰ～Ⅱ级病变可行保守治疗，Ⅲ～Ⅳ级病变则需行髌股关节表面置换术。
The ultrastructure of diseased articular cartilage, subchondral bone and synovial tissue in 10 patients with patellofemoral joint osteoarthrosis was studied. The experimental results show that: (1) Articular cartilage, subchondral bone and synovial tissue in patients with patellofemoral joint osteoarthrosis showed varying degrees of ultrastructural changes. (2) The medial patellofemoral joint space was grade Ⅰ ~ Ⅱ degeneration, mainly due to the lack of appropriate load stimulation of the site articular cartilage degeneration; the lateral gap was Ⅲ ~ Ⅳ grade degeneration, mainly due to the stock four Atrophy of the medial head, patellar subluxation, resulting in local stress concentration, articular surface continuous impact, wear and tear caused. (3) Subchondral bone showed a strong hardening trend, the change may be later than or parallel to the change of articular cartilage, the variation of the nature of the load. (4) The degeneration of grade Ⅰ ~ Ⅱ cartilage degeneration is more similar to that of normal cartilage, while the grade Ⅲ ~ Ⅳ degeneration is more like fibrocartilage, the difference may be due to the different source of the repair tissue . (5) The change of synovial tissue is a non-specific inflammatory reaction secondary to the degeneration of articular cartilage, and can further aggravate the degeneration of the former. (6) Clinical conservative treatment of grade Ⅰ ~ Ⅱ lesions, grade Ⅲ ~ Ⅳ lesions need to be treated with patellofemoral joint surface replacement.