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已知妇女垂体对促性腺激素释放激素(GnRH)刺激释放LH和FSH的反应随血中雌激素水平升高而增强,以前我们已指出每天给予炔雌醇(EE)30～40μg对于由GnRH刺激引起的LH和FSH释放增强效应可因同时给予孕激素(低剂量单相复合型OC)所抵消,抑制的程度取决于所给孕激素的类型和剂量。本文中作者用GnRH二次刺激法比较了序贯法和复合型OC(单相和双相型)中各种孕激素对垂体促性腺激素释放的影响。研究包括25名19～33岁、健康、有规则月经的妇女,按所选用的OC分为下列几组:A组8人,给EE50μg 7天后,给EE50μg+地索高诺酮(DG)0.125mg15天;B组6人,给EE50μg 7天后,给
It is known that the response of the pituitary gland to gonadotropin-releasing hormone (GnRH) -stimulated release of LH and FSH is enhanced with elevated levels of estrogen in the blood. We have previously indicated that administration of ethinylestradiol (EE) 30-40 μg daily for GnRH-stimulated The increased LH and FSH release effects can be counteracted by the simultaneous administration of progestins (low-dose single-phase complex OC) depending on the type and dose of progestogen administered. In this study, we compared the effects of various progestins in sequential and compound OC (single and biphasic) on pituitary gonadotropin release by GnRH secondary stimulation. The study included 25 women aged 19-33 years with healthy, regular menstruation who were divided into the following groups on the basis of their choice of OC: Group A, 8 for EE 50 μg, 7 days after giving EE50 μg + desopogon (DG) 0.125 mg 15 Day; Group B 6, give EE50μg 7 days later