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何杰金氏淋巴瘤也称何杰金氏病(HD),是淋巴瘤的一种。其特征性的组织学变化为骨髓涂片或骨髓活检标本中可发现Reed-Sternberg细胞。目前多数学者认为R-S细胞是诊断HD的重要形态学依据。HD最易侵犯淋巴结,尤以颈、腋窝和腹股沟淋巴结为常见,其次好发于肠系膜和纵隔淋巴结。大多数HD患者都有严重的免疫缺陷。最近几年,国外学者对HD的免疫功能异常,进行大量研究,并取得较大进展。本文就此作一文献综述。肿瘤细胞的起源近10多年研究表明,HD是一种恶性肿瘤,其R-S细胞具备肿瘤细胞最重要的属性,如非整倍性、体外持续增生、克隆衍化和异种移植能力等特征。既往认为HD患者肿瘤细胞可分为二类:(1)双核或多核的巨大R-S细胞;(2)单核何杰金氏细胞。前者为变性的终末期细胞而后者才具备增生
Hodgkin’s lymphoma, also known as Hodgkin’s disease (HD), is a type of lymphoma. Its characteristic histological changes can be found in bone marrow smears or bone marrow biopsy specimens Reed-Sternberg cells. At present, most scholars believe that R-S cells is an important morphological basis for the diagnosis of HD. HD most likely to infringe the lymph nodes, especially in the neck, axillary and inguinal lymph nodes are common, followed by the mesenteric and mediastinal lymph nodes. Most HD patients have severe immunodeficiency. In recent years, foreign scholars on the abnormal immune function of HD, a large number of studies, and made great progress. This article makes a literature review. The origins of tumor cells For nearly 10 years, studies have shown that HD is a malignant tumor whose R-S cells possess the most important properties of tumor cells such as aneuploidy, persistent hyperplasia in vitro, clonal derivation and xenotransplantation. Previously, HD patients with tumor cells can be divided into two categories: (1) binuclear or multinucleated giant R-S cells; (2) Hodgkin’s cells. The former is denatured end-stage cells and the latter have hyperplasia