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[目的]评估X射线交叉互补修复基因1(X-ray repair cross complementing protein 1,XRCC1)基因Arg399Gln位点单核苷酸多态性与高加索及亚洲人群乳腺癌(breast cancer,BC)易感性的关系。[方法]检索Pub Med、Embase、中国期刊全文数据库(CNKI)、万方数据库、中国生物医学文献数据库(CBM)和中文科技期刊全文数据库(VIP)等数据库,获取有关XRCC1 Arg399Gln位点多态性与高加索及亚洲人群乳腺癌易感性关系的病例对照研究的资料,以病例组及对照组XRCC1 Arg 399Gln等位基因分布的比值比(OR)为效应指标,应用Meta分析软件Review Manager(version 5.0.10)对各研究原始数据进行统计处理及异质性检验,计算合并OR值及其95%可信区间。[结果 ]共纳入24项病例对照研究,包括15151例乳腺癌患者和17179例对照。Meta分析结果显示,XRCC1 Arg399Gln位点Gln/Gln突变型可能会增加亚洲人群乳腺癌的发病风险[Gln/Gln vs.Arg/Arg亚洲组:OR=1.20(95%CI:1.03~1.39),P=0.02;Gln/Gln vs.Arg/Arg+Arg/Gln亚洲组:OR=1.20(95%CI:1.04~1.38),P=0.01。Gln/Gln vs.Arg/Arg OR=1.01(95%CI:0.94~1.09),Z=0.35,POR=0.73;Gln/Gln+Arg/Gln vs.Arg/Arg OR=1.02(95%CI:0.95~1.09,Z=0.58,POR=0.56;Gln/Gln vs.Arg/Arg+Arg/Gln OR=1.01(95%CI:0.95~1.08),Z=0.33,POR=0.74)。[结论]XRCC1 Arg399Gln位点Gln/Gln突变型可能与亚洲人群乳腺癌易感性相关。
[Objective] To evaluate the relationship between single nucleotide polymorphisms at Arg399Gln site of X-ray repair cross complementing protein 1 (XRCC1) and susceptibility to breast cancer (BC) in Caucasians and Asians relationship. [Methods] The databases of Pub Med, Embase, CNKI, VIP database, CBM and VIP database were searched and the polymorphisms of XRCC1 Arg399Gln site were obtained. A case-control study on the relationship between susceptibility to breast cancer in Caucasians and Asian populations was performed using the OR (OR) ratio of XRCC1 Arg 399Gln alleles in case group and control group as a response indicator. Meta analysis software Review Manager (version 5.0) 10) The original data of each study were statistically processed and heterogeneity test, calculate the combined OR and its 95% confidence interval. [Results] A total of 24 case-control studies were included, including 15,151 breast cancer patients and 17,179 controls. Meta-analysis showed that the Gln / Gln mutation at the Arg399Gln site of XRCC1 may increase the risk of breast cancer in Asian populations (OR = 1.20 (95% CI: 1.03-1.39), P = 0.02; Gln / Gln vs.Arg / Arg + Arg / Gln Asia group: OR = 1.20 (95% CI: 1.04-1.38), P = 0.01. Gln / Gln vs. Arg / Arg OR = 1.01 (95% CI: 0.94-1.09), Z = 0.35, POR = 0.73; ~ 1.09, Z = 0.58, POR = 0.56; Gln / Gln vs.Arg / Arg + Arg / Gln OR = 1.01 (95% CI: 0.95-1.08), Z = 0.33, POR = 0.74). [Conclusion] The mutation of Gln / Gln in Arg399Gln site of XRCC1 may be related to the susceptibility of breast cancer in Asians.