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目的观察奥沙利铂(L-OHP)联合亚叶酸钙(CF)和氟脲嘧啶(5-FU)组成的FOLFOX4方案治疗晚期大肠癌的疗效及不良反应。方法 28例患者,给予L-OHP85 mg/m2静脉滴注2 h,第1天;CF200 mg/m2静脉滴注2 h,第1～2天;5-FU500 mg/m2静推,然后600 mg/m2持续泵入22 h,第1～2天,2周重复。化疗3个周期后评价疗效。结果完全缓解(CR)1例,部分缓解(PR)10例,稳定(SD)12例,进展(PD)5例,总有效率(CR+PR)39.3%,主要不良反应为外周神经系统毒性,消化道反应和骨髓抑制。结论 FOLFOX4方案治疗晚期大肠癌具有较好的疗效,不良反应可耐受,值得临床推广。
Objective To observe the efficacy and side effects of oxaliplatin (L-OHP) combined with folinic acid calcium (CF) and fluorouracil (5-FU) in the treatment of advanced colorectal cancer. Methods Twenty-eight patients were given intravenous infusion of L-OHP at a dose of 85 mg / m2 for 2 h on the first day. CF200 mg / m2 was given intravenously for 2 h on days 1 to 2 and then on a 5-FU 500 mg / / m2 continued to pump 22 h, 1 to 2 days, 2 weeks repeated. After 3 cycles of chemotherapy evaluation of efficacy. Results There were 1 complete remission (CR), 10 partial remission (PR), 12 stable (SD) and 5 progressive (PD) patients. The total effective rate (CR + PR) was 39.3%. The main adverse reactions were peripheral nervous system toxicity , Gastrointestinal reactions and myelosuppression. Conclusion FOLFOX4 regimen has a good curative effect in treating advanced colorectal cancer. Adverse reactions are tolerable and worthy of clinical promotion.