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喹诺酮类（ＱＮＳ）药物对胎儿及未成年人的软骨毒性作用是全世界都很关注且悬而未决的问题。一方面，动物实验显示ＱＮＳ药物能引起幼稚动物关节软骨损害，年龄越小损害越严重，且有种属特异性。另一方面，临床上孕妇及生长发育期未成年人用ＱＮＳ药物极少发现软骨损害。研究的前提要有药动学数据。ＱＮＳ向胎儿转运的药动学资料迄今仍不易获得。为确定孕妇用此类药物能否到达胎儿体内，特别是软骨中，药物浓度如何，我们用微生物单层琼脂扩散法检测了１０例因感染而应用环丙沙星（ＣＰＬＸ）的中晚期引产的孕妇血浆、羊水及胎儿血浆、软骨中环丙沙星的浓度。结果表明环丙沙星容易通过胎盘到达羊水及胎儿体内，使孕妇血药浓度降低。同时胎儿软骨对环丙沙星可能有蓄积作用。本组靶组织中ＣＰＬＸ药物浓度的数据为孕妇的临床用药及ＱＮＳ药物的软骨毒性研究提供了药理依据。
The cartilaginous effects of quinolone (QNS) drugs on fetuses and minors are a worldwide concern and unresolved issue. On the one hand, animal experiments show that QNS drugs can cause damage to articular cartilage in naive animals. The younger the more severe damage is, and there is species specificity. On the other hand, clinical pregnant women and minors in the growth and development of QNS drugs rarely found cartilage damage. The premise of the study should be pharmacokinetic data. The pharmacokinetics of QNS to the fetus has so far not been readily available. To determine whether pregnant women with these drugs can reach the fetus, especially in cartilage, the drug concentration, we use the single-layer microbial agar diffusion method for the detection of 10 cases of infection due to the use of ciprofloxacin (CPLX) in the late induction of labor Maternal plasma, amniotic fluid and fetal plasma, the concentration of ciprofloxacin in cartilage. The results show that ciprofloxacin easily through the placenta to reach the fetus and amniotic fluid, so that pregnant women reduce blood concentration. At the same time, fetal cartilage may accumulate ciprofloxacin. This group of target tissue CPLX drug concentration data for the clinical use of pregnant women and QNS drug cartilage toxicity provides a pharmacological basis.