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目的:观察“清热解毒、养阴活血法”联合调强放疗治疗鼻咽癌的临床疗效。方法:将74例鼻咽癌患者随机分为两组,各37例,其中治疗组采用“清热解毒、养阴活血法”联合调强放疗治疗,对照组单独采用调强放疗治疗。结果:治疗组均未因急性放射性反应而中断放疗,对照组6例病人因黏膜、腮腺反应严重,放疗过程停止1～2周,而后继续完成剩余的放疗计划,两组病人均无彻底放弃放疗计划;治疗组与对照组急性放射性黏膜反应程度比较有显著性差异(P<0.05);治疗组急性放射性黏膜反应发生时间为放疗后(14.32±0.45)天,对照组为放疗后(12.61±0.34)天,两组比较差异有统计学意义(P<0.01);两组病人治疗前卡氏评分比较无显著性差异(P>0.05);治疗后治疗组卡氏评分78.53±7.82,对照组为67.25±10.76,说明治疗组病人生活质量高于对照组(P<0.01);治疗组有效率91.9%,对照组为86.5%,两组比较比较无差异(P>0.05)。结论:“清热解毒、养阴活血法”联合调强放疗治疗鼻咽癌能降低放疗毒副反应,提高患者的生活质量,并且不会影响放疗的客观疗效。
Objective: To observe the clinical effect of “detoxification, nourishing yin and activating blood circulation method” combined with intensity modulated radiotherapy in the treatment of nasopharyngeal carcinoma. Methods: A total of 74 patients with nasopharyngeal carcinoma were randomly divided into two groups (n = 37). The treatment group was treated with heat detoxification and nourishing yin and activating blood circulation combined with intensity modulated radiotherapy. The control group was treated with intensity modulated radiotherapy alone. Results: In the control group, no radiation was discontinued due to acute radioactive reaction. In the control group, 6 patients died of mucosal and parotid gland reactions. The course of radiotherapy was stopped for 1 to 2 weeks. After that, the remaining radiotherapy programs were continued. (14.32 ± 0.45) days after radiotherapy and 12.61 ± 0.34 days after radiotherapy in the control group (P <0.05). The acute radiation mucosal reaction between the treatment group and the control group was significantly different (P <0.05) ) Days, there was significant difference between the two groups (P <0.01). There was no significant difference between the two groups before treatment (P> 0.05). After treatment, the Karnofsky score of the treatment group was 78.53 ± 7.82, 67.25 ± 10.76, which showed that the quality of life of patients in the treatment group was higher than that of the control group (P <0.01). The effective rate was 91.9% in the treatment group and 86.5% in the control group. There was no significant difference between the two groups (P> 0.05). Conclusion: “Qingrejiedu, Yangyinhuoxue method” combined with intensity modulated radiotherapy in the treatment of nasopharyngeal carcinoma can reduce side effects of radiotherapy and improve the quality of life of patients, and will not affect the objective efficacy of radiotherapy.