血清胱抑素C与尿微量白蛋白检测在诊断早期糖尿病肾病中的应用

• 作 者: 肖长长
• 机 构: 广东省东莞市厚街医院肾内科,
• 出 处: 中国实用医药
• 发表日期: 2015年12期
• 关键词: 血清胱抑素C 尿微量白蛋白 24 h尿蛋白 糖尿病肾病

目的探讨血清胱抑素C(Cys C)与尿微量白蛋白(m ALB)的水平对诊断早期糖尿病肾病(DN)的临床价值。方法 54例糖尿病(DM)患者,其中尿蛋白阴性患者(NA)组20例,微量蛋白尿组(MA)18例,临床蛋白尿(CDN)组16例;健康对照组15例。测定血清Cys C与24 h尿m ALB的水平,并对结果进行统计学分析。结果 DN患者的血清Cys C与尿m ALB含量随着24 h尿Pro的增加而逐渐升高,CDN、MA组血清Cys C与尿m ALB水平明显高于NA组;NA组血清Cys C与尿m ALB水平明显高于对照组;CDN组血清Cys C与尿m ALB水平显著高于MA组,差异均有统计学意义(P<0.05)。结论血清Cys C与尿m ALB一样,是诊断早期糖尿病肾病的有效指标,具有重要临床价值。

Objective To investigate the clinical value of serum cystatin C (Cys C) and urinary microalbumin (m ALB) in the diagnosis of early diabetic nephropathy (DN). Methods Totally 54 patients with diabetes mellitus (DM) were enrolled. Among them, 20 were urinary protein negative (NA), 18 were microalbuminuria (MA), 16 were clinical proteinuria (CDN) and 15 were healthy controls. The levels of serum Cys C and 24 h urine m ALB were measured and the results were statistically analyzed. Results Serum Cys C and urinary m ALB in patients with DN gradually increased with the increase of urinary Pro of 24 h. The levels of serum Cys C and urinary m ALB in CDN and MA groups were significantly higher than those in NA group. m ALB level was significantly higher than the control group; serum Cys C and urine m ALB levels in CDN group were significantly higher than the MA group, the difference was statistically significant (P <0.05). Conclusions Serum Cys C is as effective as urine m ALB in diagnosing early diabetic nephropathy and has important clinical value.